Tolterodine Pharmacology

On this episode, I discuss tolterodine pharmacology, adverse effects, and drug interactions. Tolterodine (Detrol) is an anticholinergic medication used to manage the symptoms of overactive bladder. Tolterodine's anticholinergic activity can lead to a significant number of adverse effects like dry mouth, dry eyes, constipation, and urinary retention. Elderly patients may be at greater risk for anticholinergic adverse effects from tolterodine compared to younger patients. Tolterodine can have additive effects from other anticholinergics like diphenhydramine or TCAs which enhance its potential for side effects.