319 | Lexington AI Meetup Live: The Story of AlphaFold with Founding Member Steve Crossan

In this special live recording from our Lexington AI Meetup, we sit down with Steve Crossan, a founding member of Google DeepMind’s AlphaFold team and former Google product leader. Steve helped launch groundbreaking AI research as part of the team that built AlphaFold, the model that cracked one of biology’s grand challenges.AlphaFold can predict a protein’s 3D structure using only its amino acid sequence - a task that once took scientists months or years now completed in minutes. With the release of AlphaFold 3, the model now maps not just proteins, but how they interact with DNA, RNA, drugs, and antibodies - a huge leap for drug discovery and synthetic biology.Steve breaks down the origin story of AlphaFold, the future of AI-powered science, and what’s next for healthcare, drug development, and beyond. A special thank you to Brent Seales and Randall Stevens for helping us coordinate Steve's talk during his visit in Lexington!If you'd like to stay up to date about upcoming Middle Tech events, subscribe to our newsletter at middletech.beehiiv.com.🎙 Hosted by Logan Jones & Evan Knowles00:00 – Welcome & meetup context 04:15 – Steve’s journey from Google to DeepMind & AlphaFold birth 15:24 – Hackathon origin story & early experiments 20:10 – Accuracy breakthroughs & “contact distance” insight 25:48 – AlphaFold 3, docking, and drug-design potential 30:30 – Preventative medicine & the doctor-in-your-pocket vision 39:00 – Democratizing AI: open source and startup opportunities 51:25 – Audience Q&A on data bottlenecks & engineering culture —Middle Tech is proudly supported by:KY Innovation → kyinnovation.comAwesome Inc → awesomeinc.orgDon't miss Awesome Inc's September 5 Across → Free Ticket for Middle Tech listeners