The Truth About Treatment Resistant Depression: Part Three (Nutrition and Lifestyle)

Despite decades of therapy and pharmaceutical use, most patients with major depressive disorder fail to achieve full relief.In part three of our series, Harvard-trained psychiatrist and nutrition specialist Dr. Georgia Ede shares why lifestyle interventions are actually some of the most powerful tools we have for fighting treatment resistant depression.Drawing on years of clinical practice and pioneering work in metabolic psychiatry, Dr. Ede explains how metabolic health, sleep, exercise, circadian rhythm, and nutrition directly influence brain energy. She also breaks down why nutrition (especially carbohydrate restriction and ketogenic diets) hold unique promise for restoring brain function, even in people who haven’t responded to conventional treatments like medication and therapy.This conversation covers:How treatment-resistant depression is tied to brain metabolismThe role of exercise intensity in improving symptomsHow sleep and circadian rhythm shape brain healthHow nutrition is the #1 lever for changeClinicians, researchers, and individuals navigating depression: this conversation is a powerful reminder that patients have more power than they’ve been led to believe and deserve to know the full spectrum of tools available to them. Lifestyle interventions shouldn’t be “secondary”—they’re foundational. Check out Metabolic Mind's model for metabolic psychiatry to learn more.📌 In case you missed episode 1 and 2 of our 3-part Treatment Resistant Depression series:Episode 1: Breaking the Myth: https://youtu.be/q7jg6wlD6gYEpisode 2: TMS & Psychedelics: https://youtu.be/ay4RjudumHwExpert Featured:Dr. Georgia EdeWebsite: https://www.diagnosisdiet.com/Book: https://www.diagnosisdiet.com/change-your-diet-change-your-mindYouTube: ‪@GeorgiaEdeMD‬X: https://x.com/GeorgiaEdeMDIG: https://www.instagram.com/georgiaedemd/CMEs Mentioned:Managing Major Mental Illness with Dietary Change: The New Science of Hopehttps://www.mycme.com/courses/managing-major-mental-illness-with-dietary-change-9616Brain Energy: The Metabolic Theory of Mental Illnesshttps://www.mycme.com/courses/brain-energy-the-metabolic-theory-of-mental-illness-9615Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between...